Birch Polypore - some interesting research around several cancers
Sources
Cultivation and utility of Piptoporus betulinus fruiting bodies as a source of anticancer agents
Małgorzata Pleszczyńska, Adrian Wiater, Marek Siwulski, Marta K. Lemieszek, Justyna Kunaszewska, Józef Kaczor, Wojciech Rzeski, Grzegorz Janusz, and Janusz Szczodrak
European medicinal polypores—a modern view on traditional uses. Journal of Ethnopharmacology.
Grienke U, Zöll M, Peintner U, Rollinger JM.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963449/
Abstract
Piptoporus betulinus is a wood-rotting basidiomycete used in medicine and biotechnology.
Anticancer properties of water and ethanol extracts isolated from both cultured and nature-derived fruiting bodies of P. betulinus were examined in human colon adenocarcinoma, human lung carcinoma and human breast cancer cell lines. The studies revealed antiproliferative and antimigrative properties of all the investigated extracts.
Results
The results of the in vitro studies revealed anticancer properties of extracts isolated from cultivated fruiting bodies of P. betulinus. Especially the ethanol extract PB-A1e demonstrated particularly preferred impact on investigated cancer cells The described effect was attributed to effective inhibition of both cell proliferation and migration of human lung carcinoma, human colon adenocarcinoma and human breast cancer cell lines. After successful completion of additional analyses including cytotoxicity examination, this extract could be considered for further in vivo studies.
Conclusions
This study looked at how P. betulinus might be cultured in controlled conditions, to further enable studies into extracts taken from fruiting bodies grown that way. The study highlighted that both wild-harvested and cultured fruiting bodies exhibited antiproliferative and antimigrative properties on several cancer types when extracted into both water and ethanol, but that variability in wild-harvested specimens could be reduced by culturing by the methods outlined.